The EmbryoCellect™ microarray is fundamentally different to other microarrays.
Unlike BAC or oligonucleotide arrays, where each probe contains a single DNA target ranging in size from approximately 60-150 basepairs, each feature (spot) on the EmbryoCellect™ array contains a whole chromosome library. This provides on average 1.2 million unique chromosome-specific target fragments of DNA ranging in size from approximately 200 to 4,000 basepairs.
This approach (single cell microarray to detect aneuploidy in embryos) was first described by RHS scientists from the Department of Obstetrics and Gynaecology, The University of Adelaide in 2004 1 and 2007 2 and is exclusively licensed to RHS.
This patented approach allows the EmbryoCellect™ microarray to collect test and reference signal from an entire chromosome in a single result providing a clear indication of whole chromosome count.
- Aneuploidy detection in single cells using DNA array-based comparative genomic hybridization. Hu, D. G., Webb, G., & Hussey, N. Molecular Human Reproduction 2004, 10(4), 283–9.
- Gender determination and detection of aneuploidy in single cells using DNA array-based comparative genomic hybridization. Hu, D. G., Guan, X. Y., & Hussey, N. Methods in Molecular Medicine 2007, 132, 135–151.